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課程名稱 |
高等家畜遺傳學
ADVANCED ANIMAL GENETICS |
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開課學期 |
96-2 |
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授課對象 |
生物資源暨農學院 動物科學技術學研究所 |
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授課教師 |
朱有田 |
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課號 |
AniSci7007 |
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課程識別碼 |
626 M1250 |
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班次 |
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學分 |
4 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三9,A,B,C(16:30~21:05) |
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上課地點 |
畜三 |
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備註 |
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/962angene |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
讓學生從瞭解細胞核中染色體結構而知道細胞早期胚發育之分子調控機制。從細胞核型檢測瞭解染色體異常及產生之疾病。從細胞分化學習DNA如何改變與調控未來發育方向。從細胞核之遺傳與基因烙印學習基因轉殖動物、基因剔除動物及複製動物之生產原理及其優缺點。 |
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課程目標 |
讓學生瞭解遺傳與生理間的分子機制
能獨立閱讀文獻 |
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課程要求 |
無 |
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預期每週課後學習時數 |
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Office Hours |
每週三 14:20~17:30 |
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指定閱讀 |
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參考書目 |
1.Lewin, B. 2004. Gene VIII, Oxford University Press.
2.Lodish,Besk,Matsudaira, Kaiser, Krieger, Scott,
Zipursky, Darnell. 2004. Molecular Cell Biology. Freeman
and Company. New York.
3. Rooney, D. E. 2001. Human cytogenetics. Oxford
University press
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 |
20% |
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2. |
期末考 |
20% |
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3. |
隨堂測驗 |
20% |
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4. |
作業 |
20% |
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5. |
報告 |
20% |
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週次 |
日期 |
單元主題 |
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第1週 |
2/20 |
Introduction |
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第2週 |
2/27 |
脊椎動物內分泌系統及其研究方法 |
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第3週 |
3/05 |
利用基因轉殖技術研究激性腺素的表現與調控 |
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第4週 |
3/12 |
Mammary development and cell cycle |
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第5週 |
3/19 |
1. Romanov, S. R., B. K. Kozaklewicz, C. R. Holst, M. R. Stampfer, L. M. Haupt, and T. D. Tisty. 2001. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 409: 633-637. |
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第6週 |
3/26 |
2. Expression of the telomerase catalytic subunit, hTERT, induces resistance to tra nsforming growth factor (83d2) growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc. Natl. Acad. Sci. 2001. 98(8): 4489-4503. |
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第7週 |
4/02 |
exam |
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第8週 |
4/09 |
Neuro-Endocrine |
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第9週 |
4/16 |
1. Missale, C. F. S. Boroni, A. Sigala, M. Buriani, A. Fabris, R. Leon, D. Toso, and P. Spano. 1996. Nerve growth factor in the anterior pituitary: localization in mammotrop cells and cosecretion with prolactin by a dopamine-regulated mechanism. Proc. Natl. Acad. Sci. USA 93: 4240-4245. |
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第10週 |
4/23 |
2. Shingo, T., C. Gregg, E. Enwere, H. Fujikawa, R. Hassam, C. Geary, J. C. Cross, and S. Weiss. 2003. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299: 117-120. |
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第11週 |
4/30 |
3. Liu, J. C., R. E. Baker, C. Sun, V. C. Sundmark, and H. P. Elsholtz. 2002. Activation of G0-coupled dopamine D2 receptor inhibits ERK1/ERK2 in pituitary cells. J. Biol. Chem. 277 (39): 35819-35825. |
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第12週 |
5/07 |
exam |
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第13週 |
5/14 |
1. Tao K, J. Li, J. Warner, K. MacLeod, .F. R. Miller, G. G. Sahagian,. 2001. Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines. Int. J. Oncol.. 2001 Dec;19(6):1333-1339. |
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第14週 |
5/21 |
2. Toft D. J., S. B. Rosenberg, G . Bergers, O. Volpert, D. I. Linzer. 2001. Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression Proc. Natl. Acad. Sci. U S A. 98(23):13055-13059. |
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第15週 |
5/28 |
3. Mahmoudi, M., D. Willgoss, L. Cuttle., T. Yang, B. Pat., C. Winterford. Z. Endre, D. W. Johnson, and G. C. Cobe. 2003. In vivo and in vitro models demonstrate a role for caveolin-1 in the pathogenesis of ischaemic acute renal failure. J. Pathol. 200:296-405. |
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第16週 |
6/04 |
4. Kanasaki, H., K. Fukunaga,, K. Takahashi, K. Miyazaki, and E. Miyamoto, 2000. Involvement of p38 mitogen-activated protein kinase activation in bromocriptine-induced apoptosis in rat pituitary GH3 cells. Biol. Reprod. 62: 1468-1494. |
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第17週 |
6/11 |
exam |
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